바이오분자공학연구실 (박노경 교수)

OFFICE: 차세대과학관 601호 (Y23601), 031-330-6188

LAB: 차세대과학관 629호 (Y23629)

Email: pospnk@mju.ac.kr

연구분야: 분석화학, 나노바이오소재 개발

바이오소재를 이용한 바이오고분자약물 전달법 연구

• 생체안정성 및 적합성이 우수한 DNA 나노소재와 무기 나노입자를 활용한 고효율 유전자, 단백질, 펩타이드 약물전달법 개발

환경 감응형 나노약물전달체 연구

• 효율적인 암세포 치료를 위한 pH 환경 감응형 약물전달체 및 암세포 표적 항암나노물질 개발

바이오소재 기반의 생체 안정성 에너지 저장 소자 연구

• DNA hydrogel을 활용한 생체 안정성 supercapacitor 개발

학력

• 1999~2004 Ph.D. POSTECH (Bioanalytical Chemistry)
• 1996~1998 M.S. POSTECH (Analytical Chemistry)
• 1991~1996 B.S. POSTECH (Chemistry)

주요경력

• 2015. 03. – present Assistant/Associate/Full Professor, Department of Chemistry, Myongji University
• 2010.07. – 2015. 02. 전문연구원, 삼성전자 종합기술원
• 2005.09. – 2010. 06. Research Associate, Cornell University
• 2005.02. – 2005. 08. Postdoctoral researcher, Texas A&M University

주요논문 (selected)

• 1. M Lee, J Hwang, Y Song, M Kim, S Kim, N Park* “Anti-miR21-conjugated DNA nanohydrogel for enhanced cancer therapy”, Biomaterials Advances, 2024, 169.
• 2. M Lee, M Lee, M Kim, S Kim, N Park* “Nanosized DNA hydrogel functionalized with a DNAzyme tetrahedron for highly efficient gene silencing”, Biomacromolecules, 2024, 25(8)
• 3. MZ Quazi, J Choi, M Kim, N Park* “DNA and Nanomaterials: A Functional Combination for DNA Sensing”, ACS applied bio materials, 2024, 7(2).
• 4. MZ Quazi, N Park* “DNA Hydrogel-Based Nanocomplexes with Cancer-Targeted Delivery and Light-Triggered Peptide Drug Release for Cancer-Specific Therapeutics”, ACS Biomacromolecules, 2023, 24(5), 2127-2137.
• 5. MZ Quazi, U Lee, S Park, S Shin, E Sim, H Son*, N Park* “Cancer Cell-Specific Enhanced Raman Imaging and Photothermal Therapeutic Effect Based on Reversibly pH-Responsive Gold Nanoparticles”, ACS Applied Bio Materials, 2021, 4 (12), 8377-8385.
• 6. S Park, WJ Lee, S Park, D Choi, S Kim, N Park* “Reversibly pH-responsive gold nanoparticles and their applications for photothermal cancer therapy”, Scientific reports, 2019, 9 (1), 1-9.
• 7. J. Song, M. Lee, J. Na, T. Kim, Y. Jung, G. Y. Jung, S. Kim, N. Park* “A RNA producing DNA hydrogel as a platform for a high performance RNA interference system”, Nature Communications, 2018, 9:4331..
• 8. J. Song, K. Im, S. Hwang, J. Hur, J. Nam, S. Hwang, S. Kim*, N. Park* “DNA Hydrogel Delivery Vehicle for Light-triggered and Synergistic Cancer Therapy”, Nanoscale, 2015,7, 9433-9437
• 9. J. Hur, K. Im, S. W. Kim, J. Kim, D. Chung, T. Kim, K. H. Jo, J. H. Hahn, Z. Bao, S. Hwang, N. Park* “Polypyrrole/Agarose-Based Electronically Conductive and Reversibly Restorable Hydrogel”, ACS Nano, 2014, 8, 10066-10076
• 10. J. B. Lee, S. Peng, D. Yang, Y. H. Roh, H, Funabashi, N. Park, E. J. Rice, L. Chen, R. Long, M. Wu, D. Luo* "A mechanical metamaterial made from a DNA hydrogel" Nature Nanotechnol., 2012, 7, 816–820.
• 11. N. Park, M. R. Hartman, J. Kahn, E. Rice, H. Funabashi, D. Luo* “High-Yield Cell-free Protein Production from P-gel” Nature Protocols, 2009, 4, 1759–1770
• 12. N. Park, S. Um, H. Funabashi, J. Xu, D. Luo* “A Cell-free Protein Producing Gel” Nature Materials, 2009, 8, 432–437.
• 13. W. Cheng, N. Park, M. T. Walter, M. R. Hartman, D. Luo* “Nanopatterning Selfassembled Nanoparticle Superlattices by Moulding Microdroplets” Nature Nanotechnol., 2008, 3, 682–690
• 14. S. H. Um, J. B. Lee, N. Park, S. Kwon, C. Umbach, D. Luo* “Enzyme-catalyzed Assembly of DNA Hydrogel” Nature Materials, 2006, 5, 797–801.